Psychiatry and
Behavioral Sciences

Anxiety Trials at Stanford & PAVA

Palo Alto VA Anxiety Trials

Treatment of Panic Disorder Using CO2 Biofeedback-Assisted Breathing Therapy

This 5 week drug-free study will compare two types of breathing regulation techniques to determine which is more effective in reducing panic symptoms in people with Panic Disorder. Participants will have 5 free sessions of breathing training in which they will learn specific breathing techniques at the Palo Alto Veterans Affairs Hospital. In addition, there are 3 assessments designed to track patients’ progress before and after the therapy.

We are seeking individuals age 18-65 who currently experience unexpected panic attacks. If you would like more information or you have a referral, call (650)-493-5000 ext. 66984 or e-mail songjy@stanford.edu.

Treatment of Anxiety Attacks Using CO2 Biofeedback-Assisted Breathing Therapy

Uncomfortable physical sensations are often experienced during anxiety attacks and can often make the anxiety worse. We aim to teach participants how to control their anxiety and/or panic attacks in a drug-free way by controlling the physical symptoms that accompany these attacks. We provide 5 free sessions of breathing training therapy at the Palo Alto Veterans Affairs Hospital. Inaddition, there are 3 assessments designed to track patients’ progress before and after the therapy.

We are seeking individuals age 18-65 who currently experience anxiety attacks. If you would like more information or you have a referral, call(650)-493-5000 ext. 65242 or e-mail Pearl.Chang@va.gov.

Comparison of an alpha 2-agonist (Guanfacine) and Placebo in the Treatment of Patients with Post Traumatic Stress Disorder.

A multi-site study in the VISN 21 network(Fresno, Honolulu, San Francisco,and PAD/MPD). We will be recruiting male and female veterans age 20-60 withchronic PTSD who are not on an effective medication. Contact: Jonathan Newman(650) 493-5000 ext 23348.

Sub studies to this multicenter trial include:

Sertraline in the Treatment of Panic Disorder

This 12-week open-label study of Sertraline (Zoloft) to assess whetherpharmacological treatment alters adrenal activation during a panic attacks and whether the level predicts treatment outcome. Before and during the study cortisol levels and epinephrine secretions will be obtained. Currently recruiting males and females, over 60 with a primary diagnosis of Panic Disorder (with or without agoraphobia). Contact Dr. Sara Gandy (650)493-5000 x22211.

Pagoclone in the Treatment of Panic Disorder:

This is a 10-week, double blind, placebo controlled multi site study for Pagoclone in the treatment of Panic Disorder (PD). We are looking for patients 18 and over with primary diagnoses of PD, excluding those with G.A.D, current primary depression, social phobia or OCD. Contact: Jonathan Newman (650) 493-5000 ext 23348

Pregabalin in Eldery Patients with Generalized Anxiety Disorder:

This is an 10-week, double blind, placebo controlled multi-site study of Pregabalin in the treatment of Generalized Anxiety Disorder (GAD) in the elderly. We are looking for patients age 65 and older with a diagnois of GAD, excluding demented and amnestic patients or patients with current primary MDE, social anxiety disorder or PD. Contact: Helena Young (650) 493-5000 ext 22395

Other Ongoing Grants/Research Projects:

Stanford Anxiety Trials

Therapy for Teens who have symptoms of stress after a trauma

This research study is designed to see how brain activity improves after teens participate in a well-established therapy (no medication). We are currently seeking girls (ages 12-17) who have experienced a trauma and are having upsetting memories or are feeling frightened, jumpy or irritable. Participants will receive psychotherapy, free of charge, at Stanford for approximately 16 weeks and receive brain MRI scans before and after psychotherapy. This study aims to help researchers understand and develop better treatments for teens who have experienced a trauma. Please contact Amy Garrett, PhD at 650-736-1874 for more information.

Eligibility:

Inclusion Criteria:

External links:

Cognitive Behavioral Therapy (CBT) or Mindfulness Based Stress Reduction (MBSR) for Social Anxiety Disorder

We are offering 16 sessions of Individual Cognitive Behavioral Therapy (CBT) or Group Mindfulness Based Stress Reduction (MBSR) to people with primary generalized social anxiety disorder. Eligible participants are expected to do behavioral and fMRI assessments pre and post therapy and commit to a year of follow-up contact.

We are seeking English fluent, right handed, age 21-55 individuals who are able to commute to Stanford University for therapy and assessments. Study participants need to refrain from mood/anxiety medication and additional psychotherapy during the study treatment.  Additionally, for the fMRI scan, participants need to be off of cardiovascular medication, have no metal in body, and be under 255 lbs. 

If you are interested in participating, please view our website (http://www-psych.stanford.edu/~caan/) and call (650-723-5977) or email us ( caan@psych.stanford.edu ).

Venlafaxine in Adult Generalized Anxiety

A Double-Blind, Placebo-Controlled, Parallel-Group Comparison of Venlafaxine Extended Release Capsules and Paroxetine in Adult Outpatients with Generalized Social Anxiety Disorder

Venlafaxine in Adolescent Social Anxiety

A Double-Blind, Placebo-Controlled, Parallel-Group, Flexible-Dose Study of Venlafaxine ER in Adolescent (12-18 years old) Outpatients with Social Anxiety Disorder

Social Anxiety in Children & Adolescents

A 16 Week Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Tolerability of Paroxetine in the Treatment of Children and Adolescents (Children 8-18 years old) with Social Anxiety Disorder /Social Phobia

The above trials carry the follow exclusion criteria:

For further information regarding your rights as a participant, please call (650) 723-5244 or toll free at 1-866-680-2906, or write the Stanford IRB, Administrative Panels Office, Stanford University, Stanford, CA 94305-5401.

 

Stanford Medicine Resources:

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